He, Xingxuan: search on Z-Library

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1

Epidemiological, clinical and biochemical characterization of the p.(Ala359Asp) SMPD1 variant causing Niemann–Pick disease type B

Acuña, Mariana, Martínez, Pablo, Moraga, Carol, He, Xingxuan, Moraga, Mauricio, Hunter, Bessie, Nuernberg, Peter, Gutiérrez, Rodrigo A, González, Mauricio, Schuchman, Edward H, Luis Santos, José, Miqu

Journal:

European Journal of Human Genetics

Year:

2015

Language:

english

File:

PDF, 1.34 MB

english, 2015

2

Insertional Mutagenesis of the Mouse Acid Ceramidase Gene Leads to Early Embryonic Lethality in Homozygotes and Progressive Lipid Storage Disease in Heterozygotes

Chi-Ming Li, Jae-Ho Park, Calogera M. Simonaro, Xingxuan He, Ronald E. Gordon, Adriana-Haimovitz Friedman, Desiree Ehleiter, Francois Paris, Katia Manova, Stefan Hepbiloikler, Zvi Fuks, Konrad Sandhof

Journal:

Year:

2002

Language:

english

File:

PDF, 1.55 MB

english, 2002

3

A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann–Pick disease

Xingxuan He, Fei Chen, Ari Dagan, Shimon Gatt, Edward H Schuchman

Journal:

Analytical Biochemistry

Year:

2003

Language:

english

File:

PDF, 107 KB

english, 2003

4

Characterization of common SMPD1 mutations causing types A and B Niemann-Pick disease and generation of mutation-specific mouse models

Iwan Jones, Xingxuan He, Fourogh Katouzian, Peter I. Darroch, Edward H. Schuchman

Journal:

Molecular Genetics and Metabolism

Year:

2008

Language:

english

File:

PDF, 2.32 MB

english, 2008

5

The pro-inflammatory immunophenotype of a Farber disease mouse model is ameliorated by repeated dosing with RVT-801, a developmental enzyme replacement therapy for Farber disease

Sampey, Brante P., Duke, Katie S., Sampey, Gavin C., Gaukel, Eric J., Solyom, Alexander, Wring, Stephen A., He, Xingxuan, Zhu, Changzhi, DeAngelis, Victor, Schuchman, Edward H., Coquery, Christine M.

Journal:

Molecular Genetics and Metabolism

Year:

2019

Language:

english

File:

PDF, 47 KB

english, 2019

6

Cloning and Characterization of the Full-Length cDNA and Genomic Sequences Encoding Murine Acid Ceramidase

Chi-Ming Li, Seung-Beom Hong, Guido Kopal, Xingxuan He, Thomas Linke, Wu-Shiun Hou, Jürgen Koch, Shimon Gatt, Konrad Sandhoff, Edward H. Schuchman

Journal:

Year:

1998

Language:

english

File:

PDF, 324 KB

english, 1998

7

The Human Acid Ceramidase Gene (ASAH): Structure, Chromosomal Location, Mutation Analysis, and Expression

Chi-Ming Li, Jae-Ho Park, Xingxuan He, Brynn Levy, Fei Chen, Koji Arai, David A. Adler, Christine M. Disteche, Jürgen Koch, Konrad Sandhoff, Edward H. Schuchman

Journal:

Year:

1999

Language:

english

File:

PDF, 198 KB

english, 1999

8

Identification and Characterization of the Molecular Lesion Causing Mucopolysaccharidosis Type I in Cats

Xingxuan He, Chi-Ming Li, Calogera M. Simonaro, Qi Wan, Mark E. Haskins, Robert J. Desnick, Edward H. Schuchman

Journal:

Molecular Genetics and Metabolism

Year:

1999

Language:

english

File:

PDF, 99 KB

english, 1999

9

A Fluorescence-Based, High-Throughput Sphingomyelin Assay for the Analysis of Niemann–Pick Disease and Other Disorders of Sphingomyelin Metabolism

Xingxuan He, Fei Chen, Margaret M. McGovern, Edward H. Schuchman

Journal:

Analytical Biochemistry

Year:

2002

Language:

english

File:

PDF, 143 KB

english, 2002

10

Insertional Mutagenesis of the Mouse Acid Ceramidase Gene Leads to Early Embryonic Lethality in Homozygotes and Progressive Lipid Storage Disease in Heterozygotes

Chi-Ming Li, Jae-Ho Park, Calogera M. Simonaro, Xingxuan He, Ronald E. Gordon, Adriana-Haimovitz Friedman, Desiree Ehleiter, Francois Paris, Katia Manova, Stefan Hepbildikler, Zvi Fuks, Konrad Sandhof

Journal:

Year:

2002

File:

PDF, 25 KB

2002

11

Reproductive Pathology and Sperm Physiology in Acid Sphingomyelinase-Deficient Mice

Avigdor Butler, Xingxuan He, Ronald E. Gordon, Hai-Shan Wu, Shimon Gatt, Edward H. Schuchman

Journal:

The American Journal of Pathology

Year:

2002

Language:

english

File:

PDF, 1.60 MB

english, 2002

12

Simultaneous quantitative analysis of ceramide and sphingosine in mouse blood by naphthalene-2,3-dicarboxyaldehyde derivatization after hydrolysis with ceramidase

Xingxuan He, Arie Dagan, Shimon Gatt, Edward H. Schuchman

Journal:

Analytical Biochemistry

Year:

2005

Language:

english

File:

PDF, 326 KB

english, 2005

13

Quantitative analysis of sphingosine-1-phosphate by HPLC after napthalene-2,3-dicarboxaldehyde (NDA) derivatization

Xingxuan He, Chien-Ling Huang, Edward H. Schuchman

Journal:

Journal of Chromatography B

Year:

2009

Language:

english

File:

PDF, 542 KB

english, 2009

14

Characterization of human acid sphingomyelinase purified from the media of overexpressing Chinese hamster ovary cells

Xingxuan He, Silvia R.P Miranda, Xiaoling Xiong, Arie Dagan, Shimon Gatt, Edward H Schuchman

Journal:

Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology

Year:

1999

Language:

english

File:

PDF, 4.63 MB

english, 1999

15

An Enzymatic Assay for Quantifying Sphingomyelin in Tissues and Plasma from Humans and Mice with Niemann–Pick Disease

Xingxuan He, Fei Chen, Shimon Gatt, Edward H. Schuchman

Journal:

Analytical Biochemistry

Year:

2001

Language:

english

File:

PDF, 171 KB

english, 2001

16

Novel use of the lysosomal enzyme acid ceramidase for the treatment of inflammatory lung diseases, including cystic fibrosis

Schuchman, Edward H., Clancy, John, Dimango, Emily, Petrache, Irina, Gulbins, Erich, He, Xingxuan

Journal:

Molecular Genetics and Metabolism

Year:

2015

Language:

english

File:

PDF, 68 KB

english, 2015

17

Single Fasting Plasma Glucose Versus 75-g Oral Glucose-Tolerance Test in Prediction of Adverse Perinatal Outcomes: A Cohort Study

Shen, Songying, Lu, Jinhua, Zhang, Lifang, He, Jianrong, Li, Weidong, Chen, Niannian, Wen, Xingxuan, Xiao, Wanqing, Yuan, Mingyang, Qiu, Lan, Cheng, Kar Keung, Xia, Huimin, Mol, Ben Willem J., Qiu, Xi

Journal:

Year:

2017

Language:

english

File:

PDF, 845 KB

english, 2017

18

Identification and Characterization of Eight Novel SMPD1 Mutations Causing Types A and B Niemann-Pick Disease

Desnick, Jonathan P., Kim, Jungmin, He, Xingxuan, Wasserstein, Melissa P., Simonaro, Calogera M., Schuchman, Edward H.

Journal:

Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 332 KB

english, 2010

19

Corrigendum: The Role of S1P and the Related Signaling Pathway in the Development of Tissue Fibrosis

Wang, Erjin, He, Xingxuan, Zeng, Ming

Journal:

Frontiers in Pharmacology

Year:

2020

File:

PDF, 180 KB

2020

20

Analysis of the Lung Pathology and Alveolar Macrophage Function in the Acid Sphingomyelinase–Deficient Mouse Model of Niemann-Pick Disease

Dhami, Rajwinder, He, Xingxuan, Gordon, Ronald E, Schuchman, Edward H

Journal:

Laboratory Investigation

Year:

2001

Language:

english

File:

PDF, 2.45 MB

english, 2001

21

Single fasting plasma glucose measurement compared with 75 g oral glucose-tolerance test in prediction of adverse perinatal outcomes: a prospective cohort study from China

Shen, Songying, Lu, Jinhua, Zhang, Lifang, He, Jianrong, Li, Weidong, Chen, Niannian, Wen, Xingxuan, Xiao, Wanqing, Yuan, Mingyang, Qiu, Lan, Cheng, Kar Keung, Xia, Huimin, Mol, Ben Willem J, Qiu, Xiu

Journal:

Year:

2016

Language:

english

File:

PDF, 61 KB

english, 2016

22

Comparison of subcutaneous and oral pentosan polysulfate treatment in a rat model of mucopolysaccharidosis type VI

Simonaro, Calogera M., Frohbergh, Michael, Ge, Yi, Meng, Fanli, DeAngelis, Victor A., He, Xingxuan, Schuchman, Edward H.

Journal:

Molecular Genetics and Metabolism

Year:

2014

Language:

english

File:

PDF, 45 KB

english, 2014

23

Novel biomarkers for the mucopolysaccharidoses

Simonaro, Calogera, Ge, Yi, He, Xingxuan, DeAngelis, Victor, Haskins, Mark, Dickson, Patricia, Schuchman, Edward

Journal:

Molecular Genetics and Metabolism

Year:

2013

Language:

english

File:

PDF, 77 KB

english, 2013

24

Deregulation of sphingolipid metabolism in Alzheimer's disease

Xingxuan He, Yu Huang, Bin Li, Cheng-Xin Gong, Edward H. Schuchman

Journal:

Neurobiology of Aging

Year:

2010

Language:

english

File:

PDF, 766 KB

english, 2010

25

Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes

Pan, Wei, Yu, Jingjia, Shi, Ruizheng, Yan, Lei, Yang, Tianlun, Li, Yuanjian, Zhang, Zhuohua, Yu, Guolong, Bai, Yongping, Schuchman, Edward H., He, Xingxuan, Zhang, Guogang

Journal:

Coronary Artery Disease

Year:

2014

Language:

english

File:

PDF, 402 KB

english, 2014

26

Acid Ceramidase Treatment Enhances the Outcome of Autologous Chondrocyte Implantation in a Rat Osteochondral Defect Model

Frohbergh, Michael E., Guevara, Johana M., Grelsamer, Ronald P., Barbe, Mary F., He, Xingxuan, Simonaro, Calogera M., Schuchman, Edward H.

Journal:

Osteoarthritis and Cartilage

Year:

2015

Language:

english

File:

PDF, 10.24 MB

english, 2015

27

A Fluorescence-Based High-Performance Liquid Chromatographic Assay to Determine Acid Ceramidase Activity

Xingxuan He, Chi-Ming Li, Jae-Ho Park, Arie Dagan, Shimon Gatt, Edward H. Schuchman

Journal:

Analytical Biochemistry

Year:

1999

Language:

english

File:

PDF, 92 KB

english, 1999

28

Mechanism of Glycosaminoglycan-Mediated Bone and Joint Disease: Implications for the Mucopolysaccharidoses and Other Connective Tissue Diseases

Calogera M. Simonaro, Marina D'Angelo, Xingxuan He, Efrat Eliyahu, Nataly Shtraizent, Mark E. Haskins, Edward H. Schuchman

Journal:

The American Journal of Pathology

Year:

2008

Language:

english

File:

PDF, 965 KB

english, 2008

29

RVT-801, a developmental enzyme replacement therapy for Farber disease, ameliorates characteristic features of the disease phenotype in a Farber mouse model

Duke, Katie S., Coquery, Christine M., Gaukel, Eric J., He, Xingxuan, Schuchman, Edward H., Rhodes, Melissa, Solyom, Alexander, Sampey, Brante P.

Journal:

Molecular Genetics and Metabolism

Year:

2019

Language:

english

File:

PDF, 53 KB

english, 2019

30

Acid Sphingomyelinase Deficiency Attenuates Bleomycin-Induced Lung Inflammation and Fibrosis in Mice

Dhami, Rajwinder, He, Xingxuan, Schuchman, Edward H.

Journal:

Cellular Physiology and Biochemistry

Year:

2010

Language:

english

File:

PDF, 386 KB

english, 2010

31

Cartilage and bone disease in a mouse model of Farber lipogranulomatosis and response to treatment

Schuchman, Edward H., Frohbergh, Michael, Guevara, Johana M., He, Xingxuan, DeAngelis, Victor A., Simonaro, Calogera M.

Journal:

Molecular Genetics and Metabolism

Year:

2016

Language:

english

File:

PDF, 52 KB

english, 2016

32

Molecular Cloning and Characterization of a Human cDNA and Gene Encoding a Novel Acid Ceramidase-like Protein

Seung-Beom Hong, Chi-Ming Li, Hong-Jun Rhee, Jae-Ho Park, Xingxuan He, Brynn Levy, Ook Joon Yoo, Edward H. Schuchman

Journal:

Year:

1999

Language:

english

File:

PDF, 494 KB

english, 1999

33

Pathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons

Lee, Hyun, Lee, Jong Kil, Park, Min Hee, Hong, Yu Ri, Marti, Hugo H., Kim, Hyongbum, Okada, Yohei, Otsu, Makoto, Seo, Eul-Ju, Park, Jae-Hyung, Bae, Jae-Hoon, Okino, Nozomu, He, Xingxuan, Schuchman, Ed

Journal:

Nature Communications

Year:

2014

Language:

english

File:

PDF, 5.88 MB

english, 2014

34

Enzyme replacement therapy for Farber disease: Proof-of-concept studies in cells and mice

He, Xingxuan, Dworski, Shaalee, Zhu, Changzhi, DeAngelis, Victor, Solyom, Alex, Medin, Jeffrey A., Simonaro, Calogera M., Schuchman, Edward H.

Journal:

Year:

2017

Language:

english

File:

PDF, 6.33 MB

english, 2017

35

Acid ceramidase deficiency: Clinical implications of an emerging phenotypic spectrum and potential therapies

Solyom, Alexander, Simonaro, Calogera M., He, Xingxuan, Schuchman, Edward H.

Journal:

Molecular Genetics and Metabolism

Year:

2015

Language:

english

File:

PDF, 46 KB

english, 2015

36

Proof-of-concept studies underlying enzyme replacement therapy for acid ceramidase deficiency

Schuchman, Edward H., He, Xingxuan, Dworski, Shaalee, Zhu, Changzhi, DeAngelis, Victor, Solyom, Alex, Levade, Thierry, Medin, Jeffrey A., Simonaro, Calogera M.

Journal:

Molecular Genetics and Metabolism

Year:

2017

Language:

english

File:

PDF, 50 KB

english, 2017

37

Acid ceramidase: One enzyme with multiple therapeutic uses

Schuchman, Edward, He, Xingxuan, DeAngelis, Victor, Simonaro, Calogera

Journal:

Molecular Genetics and Metabolism

Year:

2013

Language:

english

File:

PDF, 80 KB

english, 2013

38

Bone Marrow-Derived Mesenchymal Stem Cells Prevent the Loss of Niemann-Pick Type C Mouse Purkinje Neurons by Correcting Sphingolipid Metabolism and Increasing Sphingosine-1-phosphate

Hyun Lee, Jong Kil Lee, Woo-Kie Min, Jae-Hoon Bae, Xingxuan He, Edward H. Schuchman, Jae-sung Bae, Hee Kyung Jin

Journal:

Year:

2010

Language:

english

File:

PDF, 687 KB

english, 2010

39

CD40 Enhances Sphingolipids in Orbital Fibroblasts: Potential Role of Sphingosine-1-Phosphate in Inflammatory T-Cell Migration in Graves' Orbitopathy

Plöhn, Svenja, Edelmann, Bärbel, Japtok, Lukasz, He, Xingxuan, Hose, Matthias, Hansen, Wiebke, Schuchman, Edward H., Eckstein, Anja, Berchner-Pfannschmidt, Utta

Journal:

Investigative Opthalmology & Visual Science

Year:

2018

Language:

english

File:

PDF, 634 KB

english, 2018

40

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

Lloyd-Evans, Emyr, Morgan, Anthony J, He, Xingxuan, Smith, David A, Elliot-Smith, Elena, Sillence, Daniel J, Churchill, Grant C, Schuchman, Edward H, Galione, Antony, Platt, Frances M

Journal:

Nature Medicine

Year:

2008

Language:

english

File:

PDF, 646 KB

english, 2008

41

Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease

Lee, Ju Youn, Han, Seung Hoon, Park, Min Hee, Baek, Bosung, Song, Im-Sook, Choi, Min-Koo, Takuwa, Yoh, Ryu, Hoon, Kim, Seung Hyun, He, Xingxuan, Schuchman, Edward H., Bae, Jae-Sung, Jin, Hee Kyung

Journal:

Nature Communications

Year:

2018

Language:

english

File:

PDF, 2.69 MB

english, 2018

42

ACTIVATION OF SECRETORY ACID SPHINGOMYELINASE AND ELEVATION OF CERAMIDE IN PLASMA IS ASSOCIATED WITH CHRONIC HEART FAILURE

Pan, Wei, Shi, Ruizheng, Yu, Jingjia, Yan, Lei, Yang, Tianlun, He, Xingxuan, Zhang, Guogang

Journal:

Heart (BMJ Pub. Group)

Year:

2012

Language:

english

File:

PDF, 60 KB

english, 2012

43

The molecular medicine of acid ceramidase

Frohbergh, Michael, He, Xingxuan, Schuchman, Edward H.

Journal:

Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 537 KB

english, 2015

44

Ceramide and Ischemia/Reperfusion Injury

He, Xingxuan, Schuchman, Edward H.

Journal:

Journal of Lipids

Year:

2018

Language:

english

File:

PDF, 1.34 MB

english, 2018

45

Bone marrow transplantation for feline mucopolysaccharidosis I

N. Matthew Ellinwood, Marie-Anne Colle, Margaret A. Weil, Margret L. Casal, Charles H. Vite, Staci Wiemelt, Christopher W. Hasson, Thomas M. O’Malley, Xingxuan He, Ulana Prociuk, Lucie Verot, John R.

Journal:

Molecular Genetics and Metabolism

Year:

2007

Language:

english

File:

PDF, 2.27 MB

english, 2007

46

Ceramide Is Upregulated and Associated With Mortality in Patients With Chronic Heart Failure

Yu, Jingjia, Pan, Wei, Shi, Ruizheng, Yang, Tianlun, Li, Yuanjian, Yu, Guolong, Bai, Yongping, Schuchman, Edward H., He, Xingxuan, Zhang, Guogang

Journal:

Canadian Journal of Cardiology

Year:

2015

Language:

english

File:

PDF, 589 KB

english, 2015

47

Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair

Christina Tam, Vincent Idone, Cecilia Devlin, Maria Cecilia Fernandes, Andrew Flannery, Xingxuan He, Edward Schuchman, Ira Tabas and Norma W. Andrews

Journal:

The Journal of Cell Biology

Year:

2010

Language:

english

File:

PDF, 3.23 MB

english, 2010

48

Acid Ceramidase Maintains the Chondrogenic Phenotype of Expanded Primary Chondrocytes and Improves the Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells

Simonaro, Calogera M., Sachot, Sylvain, Ge, Yi, He, Xingxuan, DeAngelis, Victor A., Eliyahu, Efrat, Leong, Daniel J., Sun, Hui B., Mason, Jeffrey B., Haskins, Mark E., Richardson, Dean W., Schuchman,

Journal:

Year:

2013

Language:

english

File:

PDF, 15.09 MB

english, 2013

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